A two-dimensional bio-platform for self-sustainable microbiome - 2DMICRONET

Project description:

The symbiotic microbiome system is a key determinant of human health. Dysfunction of the gut microbiome is a problem that causes long-term health consequences in humans. Currently known microbial delivery solutions, based on various base materials, offer some improvements in the delivery of beneficial microorganisms. However, insufficient structural/chemical processing makes their surface and the material-cell interface unfavorable, preventing effective bioseeding and cooperation between microbial cells. The 2DMICRONET project aims to adapt the MXene surface to serve as a biological platform with precisely controlled morphology, structure, and chemistry for the development of efficient microdomain network systems. The project directly addresses the challenges at European and global levels related to a healthy population and improved patient well-being. Such designed MXene-based microdomains could additionally naturally exhibit therapeutic effects and effectively combat opposing pathogenic microorganisms. In the future, such self-sufficient bio-platforms may be used in innovative gut microbiome replacement therapy, which is an alternative to currently used methods.