Lensless label-free nanoscopy (NaNoLens)
Principal Investigator: Professor Maciej Trusiak
Project Team: Mikołaj Rogalski Ph.D., Piotr Arcab MSc, Karolina Niedziela BSc, Julia Dudek BSc
Partners: Warsaw University of Technology
Project duration: 01.01.2024 - 31.12.2028
Project’s Grant Amount: 1 500 000 EUR
Grant Agreement No.: 101117392
Granting Authority: the European Research Council Executive Agency (ERCEA) under the powers delegated by the European Commission
Project description:
NaNoLens project aims to develop lensless holotomographic nanoscopy in deep UV (DUV) for imaging living cells with high resolution, without the use of fluorescent markers. While the lensless technique enables a large field of view, current systems have limited spatial resolution. Using the DUV band with low illumination intensity we will overcome these limitations, enabling submicron-level imaging. The project’s innovation lies in applying DUV not for sterilization but for non-invasive studies of extracellular vesicle dynamics in living cell cultures, opening new opportunities for understanding and utilizing them. NaNoLens combines bioimaging, computational microscopy, and digital holography to create a compact, easy-to-implement tomography system for large volumes (lensless and dye-free), capable of functioning both in and outside the laboratory.
Link: https://qcilab.mchtr.pw.edu.pl/
